Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration
Introduction: The Oral Minimal Model (OMM), a differential-equations based mathematical model of glucose-insulin dynamics, utilizes data from a frequently sampled oral glucose tolerance test (OGTT) to quantify insulin sensitivity (SI). OMM-based estimates of SI can detect differences in insulin resi...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Metabolism Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589936821000025 |
| _version_ | 1818336771918790656 |
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| author | Kai Bartlette Anne-Marie Carreau Danielle Xie Yesenia Garcia-Reyes Haseeb Rahat Laura Pyle Kristen J. Nadeau Melanie Cree-Green Cecilia Diniz Behn |
| author_facet | Kai Bartlette Anne-Marie Carreau Danielle Xie Yesenia Garcia-Reyes Haseeb Rahat Laura Pyle Kristen J. Nadeau Melanie Cree-Green Cecilia Diniz Behn |
| author_sort | Kai Bartlette |
| collection | DOAJ |
| description | Introduction: The Oral Minimal Model (OMM), a differential-equations based mathematical model of glucose-insulin dynamics, utilizes data from a frequently sampled oral glucose tolerance test (OGTT) to quantify insulin sensitivity (SI). OMM-based estimates of SI can detect differences in insulin resistance (IR) across population groups and quantify effects of clinical or behavioral interventions. These estimates of SI have been validated in healthy adults using data from OGTTs with durations from 2 to 7 h. However, data demonstrating how protocol duration affects SI estimates in highly IR populations such as adolescents with obesity are limited. Methods: A 6-h frequently sampled OGTT was performed in adolescent females with obesity. Two, 3-, and 4- hour implementations of OMM assuming an exponentially-decaying rate of glucose appearance beyond measured glucose concentrations were compared to the 6-h implementation. A 4- hour OMM implementation with truncated data (4h Tr) was also considered. Results: Data from 68 participants were included (age 15.8 ± 1.2 years, BMI 35.4 ± 5.6 kg/m2). Although SI values were highly correlated for all implementations, they varied with protocol duration (2h: 2.86 ± 3.31, 3h: 2.55 ± 2.62, 4h: 2.81 ± 2.59, 4h tr: 3.13 ± 3.14, 6h: 3.06 ± 2.85 x 10-4 dl/kg/min per U/ml). SI estimates based on 2 or 3 h of data underestimated SI values, whereas 4-h SI estimates more closely approximated 6-h SI values. Discussion: These results suggest that OGTT protocol duration should be considered when implementing OMM to estimate SI in adolescents with obesity and other IR populations. |
| first_indexed | 2024-12-13T14:44:37Z |
| format | Article |
| id | doaj.art-89ba0fb90e574896b7e0997a1a945202 |
| institution | Directory Open Access Journal |
| issn | 2589-9368 |
| language | English |
| last_indexed | 2024-12-13T14:44:37Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Metabolism Open |
| spelling | doaj.art-89ba0fb90e574896b7e0997a1a9452022022-12-21T23:41:30ZengElsevierMetabolism Open2589-93682021-03-019100078Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol durationKai Bartlette0Anne-Marie Carreau1Danielle Xie2Yesenia Garcia-Reyes3Haseeb Rahat4Laura Pyle5Kristen J. Nadeau6Melanie Cree-Green7Cecilia Diniz Behn8Department of Applied Mathematics and Statistics, Colorado School of Mines, Golden, CO, 80401, USADivision of Endocrinology, Department of Pediatrics, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USADivision of Endocrinology, Department of Pediatrics, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USADivision of Endocrinology, Department of Pediatrics, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USADivision of Endocrinology, Department of Pediatrics, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USADepartment of Pediatrics, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USA; Department of Biostatics and Informatics, Colorado School of Public Health, Aurora, CO, 80045, USADivision of Endocrinology, Department of Pediatrics, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USA; Center for Women’s Health Research, Aurora, CO, USADivision of Endocrinology, Department of Pediatrics, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USA; Department of Biostatics and Informatics, Colorado School of Public Health, Aurora, CO, 80045, USADepartment of Applied Mathematics and Statistics, Colorado School of Mines, Golden, CO, 80401, USA; Division of Endocrinology, Department of Pediatrics, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USA; Corresponding author. Department of Applied Mathematics and Statistics, Colorado School of Mines 1015 14th Street, Golden, CO, 80401, USA.Introduction: The Oral Minimal Model (OMM), a differential-equations based mathematical model of glucose-insulin dynamics, utilizes data from a frequently sampled oral glucose tolerance test (OGTT) to quantify insulin sensitivity (SI). OMM-based estimates of SI can detect differences in insulin resistance (IR) across population groups and quantify effects of clinical or behavioral interventions. These estimates of SI have been validated in healthy adults using data from OGTTs with durations from 2 to 7 h. However, data demonstrating how protocol duration affects SI estimates in highly IR populations such as adolescents with obesity are limited. Methods: A 6-h frequently sampled OGTT was performed in adolescent females with obesity. Two, 3-, and 4- hour implementations of OMM assuming an exponentially-decaying rate of glucose appearance beyond measured glucose concentrations were compared to the 6-h implementation. A 4- hour OMM implementation with truncated data (4h Tr) was also considered. Results: Data from 68 participants were included (age 15.8 ± 1.2 years, BMI 35.4 ± 5.6 kg/m2). Although SI values were highly correlated for all implementations, they varied with protocol duration (2h: 2.86 ± 3.31, 3h: 2.55 ± 2.62, 4h: 2.81 ± 2.59, 4h tr: 3.13 ± 3.14, 6h: 3.06 ± 2.85 x 10-4 dl/kg/min per U/ml). SI estimates based on 2 or 3 h of data underestimated SI values, whereas 4-h SI estimates more closely approximated 6-h SI values. Discussion: These results suggest that OGTT protocol duration should be considered when implementing OMM to estimate SI in adolescents with obesity and other IR populations.http://www.sciencedirect.com/science/article/pii/S2589936821000025Insulin sensitivityMathematical modelProtocol dependenceOral glucose tolerance testPediatrics |
| spellingShingle | Kai Bartlette Anne-Marie Carreau Danielle Xie Yesenia Garcia-Reyes Haseeb Rahat Laura Pyle Kristen J. Nadeau Melanie Cree-Green Cecilia Diniz Behn Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration Metabolism Open Insulin sensitivity Mathematical model Protocol dependence Oral glucose tolerance test Pediatrics |
| title | Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration |
| title_full | Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration |
| title_fullStr | Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration |
| title_full_unstemmed | Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration |
| title_short | Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration |
| title_sort | oral minimal model based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration |
| topic | Insulin sensitivity Mathematical model Protocol dependence Oral glucose tolerance test Pediatrics |
| url | http://www.sciencedirect.com/science/article/pii/S2589936821000025 |
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