The immune microenvironment of HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma: a multiparametric quantitative and spatial analysis unveils a rationale to target treatment-naïve tumors with immune checkpoint inhibitors

The immune microenvironment of HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma: a multiparametric quantitative and spatial analysis unveils a rationale to target treatment-naïve tumors with immune checkpoint inhibitors

Abstract Background Immune checkpoint inhibitors (ICI) are approved for treatment of recurrent or metastatic oropharyngeal head and neck squamous cell carcinoma in the first- and second-line settings. However, only 15–20% of patients benefit from this treatment, a feature increasingly ascribed to th...

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Bibliographic Details
Main Authors: Anna Tosi, Beatrice Parisatto, Anna Menegaldo, Giacomo Spinato, Maria Guido, Annarosa Del Mistro, Rossana Bussani, Fabrizio Zanconati, Margherita Tofanelli, Giancarlo Tirelli, Paolo Boscolo-Rizzo, Antonio Rosato
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Head and neck squamous cell carcinoma
Human papillomavirus
Tumor microenvironment
Immunotherapy
Multiplex immunofluorescence
Oropharyngeal carcinoma
Online Access:https://doi.org/10.1186/s13046-022-02481-4

Internet

https://doi.org/10.1186/s13046-022-02481-4

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