Cleavage of LOXL1 by BMP1 and ADAMTS14 Proteases Suggests a Role for Proteolytic Processing in the Regulation of LOXL1 Function

Cleavage of LOXL1 by BMP1 and ADAMTS14 Proteases Suggests a Role for Proteolytic Processing in the Regulation of LOXL1 Function

Members of the lysyl oxidase (LOX) family catalyze the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin in the initiation step of the formation of covalent cross-links, an essential process for connective tissue maturation. Proteolysis has emerged as an important le...

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Bibliographic Details
Main Authors: Tamara Rosell-García, Sergio Rivas-Muñoz, Alain Colige, Fernando Rodriguez-Pascual
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
extracellular matrix
elastin
lysyl oxidase-like 1
proteolysis
bone morphogenetic protein 1
a disintegrin and metalloproteinase with thrombospondin motifs
Online Access:https://www.mdpi.com/1422-0067/23/6/3285

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https://www.mdpi.com/1422-0067/23/6/3285

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