An engineering probiotic producing defensin-5 ameliorating dextran sodium sulfate-induced mice colitis via Inhibiting NF-kB pathway

An engineering probiotic producing defensin-5 ameliorating dextran sodium sulfate-induced mice colitis via Inhibiting NF-kB pathway

Abstract Background Human defensin-5 (HD-5) is a key antimicrobial peptide which plays an important role in host immune defense, while the short half-life greatly limits its clinical application. The purpose of this study was to investigate the effects of an engineering probiotic producing HD-5 on i...

Full description

Bibliographic Details
Main Authors: Lishan Zeng, Jiasheng Tan, Meng Xue, Le Liu, Mingming Wang, Liping Liang, Jun Deng, Wei Chen, Ye Chen
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Translational Medicine
Subjects:
Ulcerative colitis
Defensin-5
NZ9000SHD-5
NF-κB
Mucosal barrier
Online Access:http://link.springer.com/article/10.1186/s12967-020-02272-5

Internet

http://link.springer.com/article/10.1186/s12967-020-02272-5

Similar Items