Cardioprotective function of sclerostin by reducing calcium deposition, proliferation, and apoptosis in human vascular smooth muscle cells

Cardioprotective function of sclerostin by reducing calcium deposition, proliferation, and apoptosis in human vascular smooth muscle cells

Abstract Background Sclerostin is an inhibitor of the Wnt/b-catenin pathway, which regulates bone formation, and can be expressed in vascular smooth muscle cells (VSMCs). Type 2 diabetes (T2D) is associated with an increased risk of cardiovascular disease (CVD) and increased serum and tissue express...

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Main Authors: Sheila González-Salvatierra, Cristina García-Fontana, Jesus Lacal, Francisco Andújar-Vera, Luis Martínez-Heredia, Raquel Sanabria-de la Torre, María Ferrer-Millán, Enrique Moratalla-Aranda, Manuel Muñoz-Torres, Beatriz García-Fontana
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Cardiovascular Diabetology
Subjects:
Type 2 Diabetes
Cardiovascular Diseases
Atherosclerosis
Sclerostin
Vascular smooth muscle cells
Protective role
Online Access:https://doi.org/10.1186/s12933-023-02043-8

Internet

https://doi.org/10.1186/s12933-023-02043-8

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