Mass Spectrometric Metabolic Fingerprinting of 2-Deoxy-D-Glucose (2-DG)-Induced Inhibition of Glycolysis and Comparative Analysis of Methionine Restriction versus Glucose Restriction under Perfusion Culture in the Murine L929 Model System

Mass Spectrometric Metabolic Fingerprinting of 2-Deoxy-D-Glucose (2-DG)-Induced Inhibition of Glycolysis and Comparative Analysis of Methionine Restriction versus Glucose Restriction under Perfusion Culture in the Murine L929 Model System

All forms of restriction, from caloric to amino acid to glucose restriction, have been established in recent years as therapeutic options for various diseases, including cancer. However, usually there is no direct comparison between the different restriction forms. Additionally, many cell culture ex...

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Bibliographic Details
Main Authors: Julian Manuel Volland, Johannes Kaupp, Werner Schmitz, Anna Chiara Wünsch, Julia Balint, Marc Möllmann, Mohamed El-Mesery, Kyra Frackmann, Leslie Peter, Stefan Hartmann, Alexander Christian Kübler, Axel Seher
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
amino acid restriction
glucose restriction
mass spectrometry
low carb
2-deoxy-D-glucose
2-DG
Online Access:https://www.mdpi.com/1422-0067/23/16/9220

Internet

https://www.mdpi.com/1422-0067/23/16/9220

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