Hierarchical Clustering and Trajectory Analyses Reveal Viremia-Independent B-Cell Perturbations in HIV-2 Infection

Hierarchical Clustering and Trajectory Analyses Reveal Viremia-Independent B-Cell Perturbations in HIV-2 Infection

Time to AIDS in HIV-2 infection is approximately twice as long compared to in HIV-1 infection. Despite reduced viremia, HIV-2-infected individuals display signs of chronic immune activation. In HIV-1-infected individuals, B-cell hyperactivation is driven by continuous antigen exposure. However, the...

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Bibliographic Details
Main Authors: Emil Johansson, Priscilla F. Kerkman, Lydia Scharf, Jacob Lindman, Zsófia I. Szojka, Fredrik Månsson, Antonio Biague, Patrik Medstrand, Hans Norrgren, Marcus Buggert, Annika C. Karlsson, Mattias N. E. Forsell, Joakim Esbjörnsson, Marianne Jansson, the SWEGUB CORE Group
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
HIV-1
HIV-2
viremia
B-cell phenotype
T-bet
CD95
Online Access:https://www.mdpi.com/2073-4409/11/19/3142

Internet

https://www.mdpi.com/2073-4409/11/19/3142

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