A dominant, recombination-defective allele of Dmc1 causing male-specific sterility.

A dominant, recombination-defective allele of Dmc1 causing male-specific sterility.

DMC1 is a meiosis-specific homolog of bacterial RecA and eukaryotic RAD51 that can catalyze homologous DNA strand invasion and D-loop formation in vitro. DMC1-deficient mice and yeast are sterile due to defective meiotic recombination and chromosome synapsis. The authors identified a male dominant s...

Full description

Bibliographic Details
Main Authors: Laura A Bannister, Roberto J Pezza, Janet R Donaldson, Dirk G de Rooij, Kerry J Schimenti, R Daniel Camerini-Otero, John C Schimenti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-05-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1847842?pdf=render

Internet

http://europepmc.org/articles/PMC1847842?pdf=render

Similar Items