Chronic dantrolene treatment attenuates cardiac dysfunction and reduces atrial fibrillation inducibility in a rat myocardial infarction heart failure modelKey Findings

Chronic dantrolene treatment attenuates cardiac dysfunction and reduces atrial fibrillation inducibility in a rat myocardial infarction heart failure modelKey Findings

Background: Cardiac ryanodine receptor 2 (RyR2) dysfunction and elevated diastolic Ca2+ leak have been linked to arrhythmogenesis not only in inherited arrhythmia syndromes but also in acquired forms of heart disease including heart failure (HF) and atrial fibrillation (AF). Thus, stabilizing RyR2 m...

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Bibliographic Details
Main Authors: Colleen Nofi, DO, Kuo Zhang, MD, PhD, Yi-Da Tang, MD, PhD, Ying Li, BS, Allan Migirov, MBS, Kaie Ojamaa, PhD, A. Martin Gerdes, PhD, Youhua Zhang, MD, PhD
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Heart Rhythm O2
Subjects:
Atrial fibrillation
Cardiac ryanodine receptor
Dantrolene
Heart failure
Ryanodine receptor stabilizer
Online Access:http://www.sciencedirect.com/science/article/pii/S266650182030012X

Internet

http://www.sciencedirect.com/science/article/pii/S266650182030012X

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