A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity.

A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity.

Telomerase, a unique reverse transcriptase that specifically extends the ends of linear chromosomes, is up-regulated in the vast majority of cancer cells. Here, we show that an indole nucleotide analog, 5-methylcarboxyl-indolyl-2'-deoxyriboside 5'-triphosphate (5-MeCITP), functions as an i...

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Bibliographic Details
Main Authors: Wilnelly Hernandez-Sanchez, Wei Huang, Brian Plucinsky, Nelson Garcia-Vazquez, Nathaniel J Robinson, William P Schiemann, Anthony J Berdis, Emmanuel Skordalakes, Derek J Taylor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-04-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000204

Internet

https://doi.org/10.1371/journal.pbio.3000204

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