Inhibition of 5‐Hydroxytryptamine Receptor 2B Reduced Vascular Restenosis and Mitigated the β‐Arrestin2–Mammalian Target of Rapamycin/p70S6K Pathway

Inhibition of 5‐Hydroxytryptamine Receptor 2B Reduced Vascular Restenosis and Mitigated the β‐Arrestin2–Mammalian Target of Rapamycin/p70S6K Pathway

BackgroundAs a monoamine neurotransmitter, 5‐hydroxytryptamine (5‐HT) or serotonin modulates mood, appetite, and sleep. Besides, 5‐HT also has important peripheral functions. 5‐HT receptor 2B (5‐HT2BR) plays a key role in cardiovascular diseases, such as pulmonary arterial hypertension and cardiac v...

Full description

Bibliographic Details
Main Authors: Yahan Liu, Zhipeng Wang, Jing Li, Yiqian Ban, Guangmei Mao, Man Zhang, Mo Wang, Yan Liu, Beilei Zhao, Qiang Shen, Qingbo Xu, Nanping Wang
Format: Article
Language:English
Published: Wiley 2018-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
5‐HT receptor 2B
mammalian target of rapamycin
migration
restenosis
β‐arrestin
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.006810

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.117.006810

Similar Items