Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity

Summary: CCR7-triggered DC migration toward draining lymph nodes is critical for the initiation of protective immunity and maintenance of immune tolerance. How to promote CCR7-mediated DC migration to determine T cell responses under inflammatory and homeostatic conditions remains poorly understood....

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Bibliographic Details
Main Authors: Juan Liu, Yujie Cheng, Xiaomin Zhang, Yali Chen, Ha Zhu, Kun Chen, Shuxun Liu, Zhiqing Li, Xuetao Cao
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723000025