Enhancement of adenosine A2A signaling improves dopamine D2 receptor antagonist-induced dyskinesia via β-arrestin signaling

Enhancement of adenosine A2A signaling improves dopamine D2 receptor antagonist-induced dyskinesia via β-arrestin signaling

Repeated administration of dopamine D2 receptor (D2R) antagonists, which is the treatment for psychosis, often causes tardive dyskinesia (TD). Despite notable clinical demand, effective treatment for TD has not been established yet. The neural mechanism involving the hyperinhibition of indirect path...

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Bibliographic Details
Main Authors: Koki Nagaoka, Nozomi Asaoka, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Neuroscience
Subjects:
adenosine A2A receptor
β-arrestin
dopamine D2 receptor
indirect pathway medium spiny neuron
tardive dyskinesia
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.1082375/full

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https://www.frontiersin.org/articles/10.3389/fnins.2022.1082375/full

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