Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection.

Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection.

The broad applicability of RNA aptamers as cell-specific delivery tools for therapeutic reagents depends on the ability to identify aptamer sequences that selectively access the cytoplasm of distinct cell types. Towards this end, we have developed a novel approach that combines a cell-based selectio...

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Bibliographic Details
Main Authors: William H Thiel, Thomas Bair, Andrew S Peek, Xiuying Liu, Justin Dassie, Katie R Stockdale, Mark A Behlke, Francis J Miller, Paloma H Giangrande
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3433472?pdf=render

Internet

http://europepmc.org/articles/PMC3433472?pdf=render

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