Clinical course in two children with Juvenile Paget's disease during long-term treatment with intravenous bisphosphonates

Clinical course in two children with Juvenile Paget's disease during long-term treatment with intravenous bisphosphonates

Juvenile Paget disease (JPD) is an ultra-rare disease, characterized by loss of function of osteoprotegerin. Osteoprotegerin inhibits osteoclast activation via the receptor activator of nuclear factor κB (RANK) pathway. Severely affected children suffer from bone deformities and pain and require lon...

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Bibliographic Details
Main Authors: Jakob Höppner, Katja Steff, Barbara M. Misof, Michael M. Schündeln, Matthias Hövel, Thomas Lücke, Corinna Grasemann
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Bone Reports
Subjects:
Juvenile Paget's disease
Long-term bisphosphonates
Motor development
Histomorphometry
Bone turnover
Online Access:http://www.sciencedirect.com/science/article/pii/S2352187221000176

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http://www.sciencedirect.com/science/article/pii/S2352187221000176

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