Arenobufagin induces MCF-7 cell apoptosis by promoting JNK-mediated multisite phosphorylation of Yes-associated protein

Abstract Background It has been demonstrated that bufadienolides exert potent anti-cancer activity in various tumor types. However, the mechanisms that underlie their anti-cancer properties remain unclear. Yes-associated protein, a key effector of Hippo signaling, functions as a transcription coacti...

Full description

Bibliographic Details
Main Authors: Li-Juan Deng, Ming Qi, Qun-Long Peng, Min-Feng Chen, Qi Qi, Jia-Yan Zhang, Nan Yao, Mao-Hua Huang, Xiao-Bo Li, Yin-Hui Peng, Jun-Shan Liu, Deng-Rui Fu, Jia-Xu Chen, Wen-Cai Ye, Dong-Mei Zhang
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Cancer Cell International
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12935-018-0706-9