Tumor analysis of MMR genes in Lynch‐like syndrome: Challenges associated with results interpretation

Tumor analysis of MMR genes in Lynch‐like syndrome: Challenges associated with results interpretation

Abstract Background Up to 70% of suspected Lynch syndrome patients harboring MMR deficient tumors lack identifiable germline pathogenic variants in MMR genes, being referred to as Lynch‐like syndrome (LLS). Previous studies have reported biallelic somatic MMR inactivation in a variable range of LLS‐...

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Bibliographic Details
Main Authors: Paula Rofes, Núria Dueñas, Jesús delValle, Matilde Navarro, Judith Balmaña, Teresa Ramón y Cajal, Noemí Tuset, Carmen Castillo, Sara González, Joan Brunet, Gabriel Capellá, Conxi Lázaro, Marta Pineda
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Cancer Medicine
Subjects:
clinical management
Lynch syndrome
Lynch‐like syndrome
mismatch repair genes
mismatch repair‐deficiency
tumor testing
Online Access:https://doi.org/10.1002/cam4.7041

Internet

https://doi.org/10.1002/cam4.7041

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