Elevated ASCL1 activity creates de novo regulatory elements associated with neuronal differentiation

Elevated ASCL1 activity creates de novo regulatory elements associated with neuronal differentiation

Abstract Background The pro-neural transcription factor ASCL1 is a master regulator of neurogenesis and a key factor necessary for the reprogramming of permissive cell types to neurons. Endogenously, ASCL1 expression is often associated with neuroblast stem-ness. Moreover, ASCL1-mediated reprogrammi...

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Bibliographic Details
Main Authors: Laura M. Woods, Fahad R. Ali, Roshna Gomez, Igor Chernukhin, Daniel Marcos, Lydia M. Parkinson, Ahmad N. Abou Tayoun, Jason S. Carroll, Anna Philpott
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Genomics
Subjects:
ASCL1
Reprogramming
Neuroblastoma
Induced neurons
Differentiation
Online Access:https://doi.org/10.1186/s12864-022-08495-8

Internet

https://doi.org/10.1186/s12864-022-08495-8

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