Induction of blood brain barrier tight junction protein alterations by CD8 T cells.

Disruption of the blood brain barrier (BBB) is a hallmark feature of immune-mediated neurological disorders as diverse as viral hemorrhagic fevers, cerebral malaria and acute hemorrhagic leukoencephalitis. Although current models hypothesize that immune cells promote vascular permeability in human d...

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Bibliographic Details
Main Authors: Georgette L Suidan, Jeremiah R Mcdole, Yi Chen, Istvan Pirko, Aaron J Johnson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2516328?pdf=render