Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences

ABSTRACT HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the surface of virus-infected cells, thus evading immune detection by CD8+ T cells. Polymorphic residues within the HLA cytoplasmic region may affect Nef’s downregulation activity. However, t...

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Bibliographic Details
Main Authors: Macdonald Mahiti, Mako Toyoda, Xiaofei Jia, Xiaomei T. Kuang, Francis Mwimanzi, Philip Mwimanzi, Bruce D. Walker, Yong Xiong, Zabrina L. Brumme, Mark A. Brockman, Takamasa Ueno
Format: Article
Language:English
Published: American Society for Microbiology 2016-03-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.01516-15

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https://journals.asm.org/doi/10.1128/mBio.01516-15

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