Rac1 Modulates Endothelial Function and Platelet Aggregation in Diabetes Mellitus

Rac1 Modulates Endothelial Function and Platelet Aggregation in Diabetes Mellitus

BackgroundVascular complications and abnormal platelet function contribute to morbidity and mortality in diabetes mellitus. We hypothesized that the Rho‐related GTPase protein, Rac1, can influence both endothelial and platelet function and might represent a potential novel therapeutic target in diab...

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Bibliographic Details
Main Authors: Gabriele Giacomo Schiattarella, Albino Carrizzo, Federica Ilardi, Antonio Damato, Mariateresa Ambrosio, Michele Madonna, Valentina Trimarco, Marina Marino, Elena De Angelis, Silvio Settembrini, Cinzia Perrino, Bruno Trimarco, Giovanni Esposito, Carmine Vecchione
Format: Article
Language:English
Published: Wiley 2018-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
endothelial dysfunction
NO
oxidative stress
cardiovascular disease
vascular reactivity
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.007322

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.117.007322

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