A New Treatment Opportunity for DIPG and Diffuse Midline Gliomas: 5-ALA Augmented Irradiation, the 5aai Regimen

A New Treatment Opportunity for DIPG and Diffuse Midline Gliomas: 5-ALA Augmented Irradiation, the 5aai Regimen

Prognosis for diffuse intrinsic pontine glioma (DIPG) and generally for diffuse midline gliomas (DMG) has only marginally improved over the last ~40 years despite dozens of chemotherapy and other therapeutic trials. The prognosis remains invariably fatal. We present here the rationale for a planned...

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Bibliographic Details
Main Authors: Richard E. Kast, Alex P. Michael, Iacopo Sardi, Terry C. Burns, Tim Heiland, Georg Karpel-Massler, Francois G. Kamar, Marc-Eric Halatsch
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Brain Sciences
Subjects:
5-aminolevulinic acid
diffuse intrinsic pontine glioma
diffuse midline gliomas
fluorescence
glioblastoma
irradiation
photodynamic
prognosis
protoporphyrin ix
reactive oxygen species
Online Access:https://www.mdpi.com/2076-3425/10/1/51

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https://www.mdpi.com/2076-3425/10/1/51

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