Synthesis and Evaluation of the Anticonvulsant Activities of 4-(2-(Alkylthio)benzo[d]oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazol-3-ones

Synthesis and Evaluation of the Anticonvulsant Activities of 4-(2-(Alkylthio)benzo[d]oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazol-3-ones

In this study, a novel series of 4-(2-(alkylthio)benzo[d]oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazol-3-ones (4a–m) was designed and synthesized. The anticonvulsant activities of these compounds were evaluated by using the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) s...

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Bibliographic Details
Main Authors: Ming-Xia Song, Zhen-Yuan Wang, Shi-Hui He, Sheng-Wang Yu, Shi-Long Chen, Dong-Fu Guo, Wen-Hao Zhao, Xian-Qing Deng
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
anticonvulsant
maximal electroshock
pentylenetetrazole
benzoxazole
triazolone
Online Access:http://www.mdpi.com/1420-3049/23/4/756

Internet

http://www.mdpi.com/1420-3049/23/4/756

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