TNF-alpha-induced cPLA2 expression via NADPH oxidase/reactive oxygen species-dependent NF-kappaB cascade on human pulmonary alveolar epithelial cells

TNF-alpha-induced cPLA2 expression via NADPH oxidase/reactive oxygen species-dependent NF-kappaB cascade on human pulmonary alveolar epithelial cells

Tumor necrosis factor-alpha (TNF-alpha) triggers activation of cytosolic phospholipase A2 (cPLA2) and then enhancing the synthesis of prostaglandin (PG) in inflammatory diseases. However, the detailed mechanisms of TNF-alpha induced cPLA2 expression were not fully defined in human pulmonary alveolar...

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Bibliographic Details
Main Authors: Chih-Chung Lin, Wei Ning Lin, Rou-Ling Cho, Chen-yu Wang, Li-Der Hsiao, Chuen-Mao Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Pharmacology
Subjects:
Cytokines
lung inflammation
signaling transduction
cytosolic phospholipase A2
ASK1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00447/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00447/full

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