Multifaceted Roles of DNA Methylation in Neoplastic Transformation, from Tumor Suppressors to EMT and Metastasis

Multifaceted Roles of DNA Methylation in Neoplastic Transformation, from Tumor Suppressors to EMT and Metastasis

Among the major mechanisms involved in tumorigenesis, DNA methylation is an important epigenetic modification impacting both genomic stability and gene expression. Methylation of promoter-proximal CpG islands (CGIs) and transcriptional silencing of tumor suppressors represent the best characterized...

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Bibliographic Details
Main Authors: Laura Casalino, Pasquale Verde
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Genes
Subjects:
DNA methylation
neoplastic transformation
tumor suppressors
biomarkers
epithelial-to-mesenchymal transition
metastasis
Online Access:https://www.mdpi.com/2073-4425/11/8/922

Internet

https://www.mdpi.com/2073-4425/11/8/922

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