Prediction of Minocycline Activity in the Gut From a Pig Preclinical Model Using a Pharmacokinetic -Pharmacodynamic Approach

Prediction of Minocycline Activity in the Gut From a Pig Preclinical Model Using a Pharmacokinetic -Pharmacodynamic Approach

The increase of multidrug-resistant (MDR) bacteria has renewed interest in old antibiotics, such as minocycline, that can be active against various MDR Gram-negative pathogens. The elimination of minocycline by both kidneys and liver makes it suitable for impaired renal function patients. However, t...

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Bibliographic Details
Main Authors: Quentin Vallé, Béatrice B. Roques, Alain Bousquet-Mélou, David Dahlhaus, Felipe Ramon-Portugal, Véronique Dupouy, Delphine Bibbal, Aude A. Ferran
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Microbiology
Subjects:
antibiotic
intestinal contents
binding
commensal flora
pig model
antimicrobial resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.671376/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.671376/full

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