Sialic Acid Mimetic Microglial Sialic Acid-Binding Immunoglobulin-like Lectin Agonism: Potential to Restore Retinal Homeostasis and Regain Visual Function in Age-Related Macular Degeneration

Sialic Acid Mimetic Microglial Sialic Acid-Binding Immunoglobulin-like Lectin Agonism: Potential to Restore Retinal Homeostasis and Regain Visual Function in Age-Related Macular Degeneration

Age-related macular degeneration (AMD), a leading cause of visual loss and dysfunction worldwide, is a disease initiated by genetic polymorphisms that impair the negative regulation of complement. Proteomic investigation points to altered glycosylation and loss of Siglec-mediated glyco-immune checkp...

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Bibliographic Details
Main Authors: Michael J. Tolentino, Andrew J. Tolentino, Elizabeth M. Tolentino, Anitha Krishnan, Mohamed A. Genead
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Pharmaceuticals
Subjects:
microglia
macrophages
macular degeneration
sialic acid
Siglecs
nanoparticles
Online Access:https://www.mdpi.com/1424-8247/16/12/1735

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https://www.mdpi.com/1424-8247/16/12/1735

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