Convergence of EGFR glioblastoma mutations: evolution and allostery rationalizing targeted therapy

Convergence of EGFR glioblastoma mutations: evolution and allostery rationalizing targeted therapy

EGFR mutations display striking organ-site asymmetry and heterogeneity. We have shown that structurally diverse extracellular mutations, typical of glioblastomas, converge to a similar intermediate conformation, which can be synergistically targeted extra- and intracelullarly by antibody mAb806 and...

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Bibliographic Details
Main Author: Laura Orellana
Format: Article
Language:English
Published: Taylor & Francis Group 2019-09-01
Series:Molecular & Cellular Oncology
Subjects:
egfr
ectomutations
convergence
mab806
kinase inhibitors
Online Access:http://dx.doi.org/10.1080/23723556.2019.1630798

Internet

http://dx.doi.org/10.1080/23723556.2019.1630798

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