Development of an In Vitro Membrane Model to Study the Function of EsxAB Heterodimer and Establish the Role of EsxB in Membrane Permeabilizing Activity of <i>Mycobacterium tuberculosis</i>
EsxA and EsxB are secreted as a heterodimer and have been shown to play critical roles in phagosome rupture and translocation of <i>Mycobacterium tuberculosis</i> into the cytosol. Recent in vitro studies have suggested that the EsxAB heterodimer is dissociated upon acidification, which...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/9/12/1015 |