Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly

Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly

Synaptic exocytosis depends on formation of the SNARE complex but its assembly mechanism is still under debate. Here, the authors identify an interaction between Munc13-1 and synaptobrevin-2 that is critical for the transition of the Munc18-1/syntaxin-1 complex to the SNARE complex.

Bibliographic Details
Main Authors: Shen Wang, Yun Li, Jihong Gong, Sheng Ye, Xiaofei Yang, Rongguang Zhang, Cong Ma
Format: Article
Language:English
Published: Nature Portfolio 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-08028-6

Internet

https://doi.org/10.1038/s41467-018-08028-6

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