Histone H3K27M Mutation Overrides Histological Grading in Pediatric Gliomas
Abstract Pediatric high-grade gliomas (HGG) are rare aggressive tumors that present a prognostic and therapeutic challenge. Diffuse midline glioma, H3K27M–mutant is a new entity introduced to HGG in the latest WHO classification. In this study we evaluated the presence of H3K27M mutation in 105 tumo...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2020-05-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-65272-x |