Interleukin-33 Induces Neutrophil Extracellular Trap (NET) Formation and Macrophage Necroptosis via Enhancing Oxidative Stress and Secretion of Proatherogenic Factors in Advanced Atherosclerosis

Interleukin-33 Induces Neutrophil Extracellular Trap (NET) Formation and Macrophage Necroptosis via Enhancing Oxidative Stress and Secretion of Proatherogenic Factors in Advanced Atherosclerosis

Interleukin-33 (IL-33) acts as an ‘alarmin’, and its role has been demonstrated in driving immune regulation and inflammation in many human diseases. However, the precise mechanism of action of IL-33 in regulating neutrophil and macrophage functioning is not defined in advanced atherosclerosis (aAT)...

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Bibliographic Details
Main Authors: Manoj Kumar Tembhre, Mukesh Kumar Sriwastva, Milind Padmakar Hote, Shikha Srivastava, Priyanka Solanki, Shafaque Imran, Ramakrishnan Lakshmy, Alpana Sharma, Kailash Jaiswal, Ashish Datt Upadhyay
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Antioxidants
Subjects:
Interleukin-33
NETs
necroptosis
advanced atherosclerosis
myeloperoxidases (MPO)
macrophages
Online Access:https://www.mdpi.com/2076-3921/11/12/2343

Internet

https://www.mdpi.com/2076-3921/11/12/2343

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