Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans

Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans

Proprotein convertase, subtilisin/kexin type 9 (PCSK9), a key regulator of plasma LDL-cholesterol (LDL-c) and cardiovascular risk, is produced in liver and secreted into plasma where it binds hepatic LDL receptors (LDLR), leading to their degradation. PCSK9 is transcriptionally activated by sterol r...

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Bibliographic Details
Main Authors: Jeffrey D. Browning, Jay D. Horton
Format: Article
Language:English
Published: Elsevier 2010-11-01
Series:Journal of Lipid Research
Subjects:
PCSK9
cholesterol synthesis
LDL-cholesterol
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520409708

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http://www.sciencedirect.com/science/article/pii/S0022227520409708

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