Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays

Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays

Abstract Background Aggregation of α-synuclein (α-syn) is a prominent feature of Parkinson’s disease (PD) and other synucleinopathies. Currently, α-syn seed amplification assays (SAAs) using cerebrospinal fluid (CSF) represent the most promising diagnostic tools for synucleinopathies. However, CSF i...

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Bibliographic Details
Main Authors: Giovanni Bellomo, Silvia Paciotti, Luis Concha-Marambio, Domenico Rizzo, Anna Lidia Wojdaƚa, Davide Chiasserini, Leonardo Gatticchi, Linda Cerofolini, Stefano Giuntini, Chiara Maria Giulia De Luca, Yihua Ma, Carly M. Farris, Giuseppe Pieraccini, Sara Bologna, Marta Filidei, Enrico Ravera, Moreno Lelli, Fabio Moda, Marco Fragai, Lucilla Parnetti, Claudio Luchinat
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Molecular Neurodegeneration
Subjects:
α-synuclein
Lipoproteins
Cerebrospinal fluid
Seed amplification assays
RT-QuIC
Online Access:https://doi.org/10.1186/s13024-023-00613-8

Internet

https://doi.org/10.1186/s13024-023-00613-8

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