Potential Regulatory Effects of Corticotropin-Releasing Factor on Tight Junction-Related Intestinal Epithelial Permeability are Partially Mediated by CK8 Upregulation

Potential Regulatory Effects of Corticotropin-Releasing Factor on Tight Junction-Related Intestinal Epithelial Permeability are Partially Mediated by CK8 Upregulation

Background/Aims: Intestinal permeability and stress have been implicated in the pathophysiology of irritable bowel syndrome (IBS). Cytokeratin 8 (CK8), for the first time, has been shown to mediate corticotropin-releasing factor (CRF)-induced changes in intestinal permeability in animal models of IB...

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Bibliographic Details
Main Authors: Hu Yue, Lu  Bin, Chen Chaoying, Zhang Meng, Li Meng, Wang Xi
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Intestinal epithelial permeability
Cytokeratin 8
Corticotropin-releasing factor
Tight junction protein
RhoA
Online Access:https://www.karger.com/Article/FullText/485420

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https://www.karger.com/Article/FullText/485420

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