Distinct DNA methylation patterns associated with treatment resistance in metastatic castration resistant prostate cancer

Distinct DNA methylation patterns associated with treatment resistance in metastatic castration resistant prostate cancer

Abstract Androgens are a major driver of prostate cancer (PCa) and continue to be a critical treatment target for advanced disease, which includes castration therapy and antiandrogens. However, resistance to these therapies leading to metastatic castration-resistant prostate cancer (mCRPC), and the...

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Bibliographic Details
Main Authors: Madonna R. Peter, Misha Bilenky, Alastair Davies, Ruth Isserlin, Gary D. Bader, Neil E. Fleshner, Martin Hirst, Amina Zoubeidi, Bharati Bapat
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-85812-3

Internet

https://doi.org/10.1038/s41598-021-85812-3

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