Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats

Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats

Abstract Aims/introduction As a common complication in elderly patients after surgery/anesthesia, postoperative cognitive dysfunction (POCD) is mainly characterized by memory, attention, motor, and intellectual retardation. Neuroinflammation is one of the most uncontroversial views in POCD. The sevo...

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Bibliographic Details
Main Authors: Junjie Zhou, Chao Zhang, Xu Fang, Naixin Zhang, Xiaoxi Zhang, Zhaoqiong Zhu
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Neuroscience
Subjects:
Autophagy
Elderly rat
Nucleotide‐binding oligomerization domain‐like receptor protein 3 inflammasome
Sevoflurane
Online Access:https://doi.org/10.1186/s12868-023-00777-5

Internet

https://doi.org/10.1186/s12868-023-00777-5

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