Large‐scale heparin‐based bind‐and‐elute chromatography identifies two biologically distinct populations of extracellular vesicles

Large‐scale heparin‐based bind‐and‐elute chromatography identifies two biologically distinct populations of extracellular vesicles

ABSTRACT Purifying extracellular vesicles (EVs) has been challenging because EVs are heterogeneous in cargo yet share similar sizes and densities. Most surface marker‐based affinity separation methods are limited to research or diagnostic scales. We report that heparin chromatography can separate pu...

Full description

Bibliographic Details
Main Authors: Yijun Zhou, Runjie Yuan, Allaura S. Cone, Kyle W. Shifflett, Gabriel F. Arias, Alice Peng, Meredith G. Chambers, Ryan P. McNamara, Smaranda Willcox, Justin T. Landis, Yue Pan, Jack Griffith, Dirk P. Dittmer
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:Journal of Extracellular Vesicles
Subjects:
heparin
fibronectin
extracellular vesicles
extracellular particles
exosome
exomere
Online Access:https://doi.org/10.1002/jev2.12327

Internet

https://doi.org/10.1002/jev2.12327

Similar Items