Low doses of gamma ionizing radiation increase hprt mutant frequencies of TK6 cells without triggering the mutator phenotype pathway

Low doses of gamma ionizing radiation increase hprt mutant frequencies of TK6 cells without triggering the mutator phenotype pathway

The TK6 lymphoblastoid cell line is known to be mismatch repair (MMR) and p53 proficient. Deficiency in MMR results in a mutator phenotype characterized by microsatellite instability (MSI) and increased hprt mutant frequency (MF). Increased hprt MF is also a biomarker of effect for exposure to ioniz...

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Bibliographic Details
Main Authors: Flávio Monteiro Ayres, Aparecido Divino da Cruz, Patricia Steele, Barry W. Glickman
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2006-01-01
Series:Genetics and Molecular Biology
Subjects:
mutator phenotype
hprt
microsatellite instability
TK6 cells
ionizing radiation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000300027

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000300027

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