CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility

CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility

We report that the Gm7068 (CatSpere) and Tex40 (CatSperz) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption of CatSperz reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe male subfertility. Normally distributed in linear qua...

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Bibliographic Details
Main Authors: Jean-Ju Chung, Kiyoshi Miki, Doory Kim, Sang-Hee Shim, Huanan F Shi, Jae Yeon Hwang, Xinjiang Cai, Yusuf Iseri, Xiaowei Zhuang, David E Clapham
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-02-01
Series:eLife
Subjects:
mammalian fertilization
sperm motility
rheotaxis
Ca2+ channels
super-resolution imaging
Online Access:https://elifesciences.org/articles/23082

Internet

https://elifesciences.org/articles/23082

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