The Protective Effects of Parathyroid Hormone (1‐34) on Cartilage and Subchondral Bone Through Down‐Regulating JAK2/STAT3 and WNT5A/ROR2 in a Collagenase‐Induced Osteoarthritis Mouse Model

The Protective Effects of Parathyroid Hormone (1‐34) on Cartilage and Subchondral Bone Through Down‐Regulating JAK2/STAT3 and WNT5A/ROR2 in a Collagenase‐Induced Osteoarthritis Mouse Model

Objective To assess the effects of PTH (1‐34) on bone and cartilage metabolism in a collagenase‐induced mouse model of osteoarthritis (OA) and examine whether PTH (1‐34) affects the expression of JAK2/STAT3 and WNT5A/ROR2 in this process. Methods Eighteen 12‐week‐old male C57Bl/6 mice were randomly...

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Bibliographic Details
Main Authors: Li‐tao Shao, Yu Gou, Jia‐kang Fang, Yun‐peng Hu, Qiang‐qiang Lian, Zhou Yang, Yu‐ying Zhang, Yu‐dan Wang, Fa‐ming Tian, Liu Zhang
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Orthopaedic Surgery
Subjects:
Cartilage
JAK2
Osteoarthritis
Parathyroid hormone
Subchondral bone
Online Access:https://doi.org/10.1111/os.13019

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