Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytes

Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytes

<p>Abstract</p> <p>Background</p> <p>The classic neuritic β-amyloid plaque of Alzheimer's disease (AD) is typically associated with activated microglia and neuroinflammation. Similarly, cerebrovascular β-amyloid (Aβ) deposits are surrounded by perivascular macropha...

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Bibliographic Details
Main Authors: Kornhuber Johannes, Lewczuk Piotr, Smirnov Alexander, Klafki Hans-Wolfgang, Herrmann Martin, Spitzer Philipp, Wiltfang Jens, Maler Juan
Format: Article
Language:English
Published: BMC 2010-10-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/7/1/59

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http://www.jneuroinflammation.com/content/7/1/59

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