Remodeling of lumbar motor circuitry remote to a thoracic spinal cord injury promotes locomotor recovery

Remodeling of lumbar motor circuitry remote to a thoracic spinal cord injury promotes locomotor recovery

Retrogradely-transported neurotrophin signaling plays an important role in regulating neural circuit specificity. Here we investigated whether targeted delivery of neurotrophin-3 (NT-3) to lumbar motoneurons (MNs) caudal to a thoracic (T10) contusive spinal cord injury (SCI) could modulate dendritic...

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Bibliographic Details
Main Authors: Ying Wang, Wei Wu, Xiangbing Wu, Yan Sun, Yi P Zhang, Ling-Xiao Deng, Melissa Jane Walker, Wenrui Qu, Chen Chen, Nai-Kui Liu, Qi Han, Heqiao Dai, Lisa BE Shields, Christopher B Shields, Dale R Sengelaub, Kathryn J Jones, George M Smith, Xiao-Ming Xu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-09-01
Series:eLife
Subjects:
NT-3
retrograde transport
lumbar motoneuron
dendritic morphology
plasticity
spinal cord injury
Online Access:https://elifesciences.org/articles/39016

Internet

https://elifesciences.org/articles/39016

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