N3ICD with the transmembrane domain can effectively inhibit EMT by correcting the position of tight/adherens junctions

N3ICD with the transmembrane domain can effectively inhibit EMT by correcting the position of tight/adherens junctions

EMT allows a polarized epithelium to lose epithelial integrity and acquire mesenchymal characteristics. Previously, we found that overexpression of the intracellular domain of Notch3 (N3ICD) can inhibit EMT in breast cancer cells. In this study, we aimed to elucidate the influence of N3ICD or N3ICD...

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Bibliographic Details
Main Authors: Junyu Tan, Xixun Zhang, Wenjun Xiao, Xiong Liu, Chun Li, Yuxian Guo, Wei Xiong, Yaochen Li
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Cell Adhesion & Migration
Subjects:
breast cancer
notch3
cell-cell junctions
emt (epithelial to mesenchymal transition)
cell polarity
Online Access:http://dx.doi.org/10.1080/19336918.2019.1619958

Internet

http://dx.doi.org/10.1080/19336918.2019.1619958

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