A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3

A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3

Summary: Pulmonary arterial hypertension (PAH) features pathogenic and abnormal endothelial cells (ECs), and one potential origin is clonal selection. We studied the role of p53 and toll-like receptor 3 (TLR3) in clonal expansion and pulmonary hypertension (PH) via regulation of bone morphogenetic p...

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Bibliographic Details
Main Authors: Aneel R. Bhagwani, Mehboob Ali, Bryce Piper, Mingjun Liu, Jaylen Hudson, Neil Kelly, Srimathi Bogamuwa, Hu Yang, James D. Londino, Joseph S. Bednash, Daniela Farkas, Rama K. Mallampalli, Mark R. Nicolls, John J. Ryan, A.A. Roger Thompson, Stephen Y. Chan, Delphine Gomez, Elena A. Goncharova, Laszlo Farkas
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223000123

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http://www.sciencedirect.com/science/article/pii/S2589004223000123

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