Unravelling the mechanism of neurotensin recognition by neurotensin receptor 1

Unravelling the mechanism of neurotensin recognition by neurotensin receptor 1

Abstract The conformational ensembles of G protein-coupled receptors (GPCRs) include inactive and active states. Spectroscopy techniques, including NMR, show that agonists, antagonists and other ligands shift the ensemble toward specific states depending on the pharmacological efficacy of the ligand...

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Bibliographic Details
Main Authors: Kazem Asadollahi, Sunnia Rajput, Lazarus Andrew de Zhang, Ching-Seng Ang, Shuai Nie, Nicholas A. Williamson, Michael D. W. Griffin, Ross A. D. Bathgate, Daniel J. Scott, Thomas R. Weikl, Guy N. L. Jameson, Paul R. Gooley
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44010-7

Internet

https://doi.org/10.1038/s41467-023-44010-7

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