GMP development and preclinical validation of CAR-T cells targeting a lytic EBV antigen for therapy of EBV-associated malignancies

GMP development and preclinical validation of CAR-T cells targeting a lytic EBV antigen for therapy of EBV-associated malignancies

IntroductionEpstein-Barr virus (EBV) is a widely spread pathogen associated with lymphoproliferative diseases, B/ T/ NK cell lymphomas, nasopharyngeal carcinoma (NPC) and gastric carcinoma (GC). EBV lytic reactivations contribute to the genomic instability, inflammation and tumorigenesis of NPC, pro...

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Bibliographic Details
Main Authors: Xi Zhang, Tiaoxia Wang, Xiaona Zhu, Yong Lu, Mingpeng Li, Zhihong Huang, Deping Han, Longzhen Zhang, Yang Wu, Liantao Li, Frank Klawonn, Renata Stripecke
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
CAR-T cell
GMP
EBV
gp350
nasopharyngeal carcinoma
gastric carcinoma
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1103695/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1103695/full

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