Opiates Modulate Thermosensation by Internalizing Cold Receptor TRPM8

Opiates Modulate Thermosensation by Internalizing Cold Receptor TRPM8

Stimulation of μ-opioid receptors (OPRMs) brings powerful pain relief, but it also leads to the development of tolerance and addiction. Ensuing withdrawal in abstinent patients manifests itself with severe symptoms, including cold hyperalgesia, often preventing addicted patients from successfully co...

Full description

Bibliographic Details
Main Authors: George Shapovalov, Dimitra Gkika, Maily Devilliers, Artem Kondratskyi, Dmitri Gordienko, Jerome Busserolles, Alexandre Bokhobza, Alain Eschalier, Roman Skryma, Natalia Prevarskaya
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713003495

Internet

http://www.sciencedirect.com/science/article/pii/S2211124713003495

Similar Items