Exosomal HMGB1 derived from hypoxia‐conditioned bone marrow mesenchymal stem cells increases angiogenesis via the JNK/HIF‐1α pathway

Exosomal HMGB1 derived from hypoxia‐conditioned bone marrow mesenchymal stem cells increases angiogenesis via the JNK/HIF‐1α pathway

Mesenchymal stem cells (MSCs) have been described to induce angiogenesis in various tissues and have been used for the development of novel cell‐based therapies. Increasing evidence suggests that MSCs execute their paracrine function via the secretion of exosomes, especially under hypoxic conditions...

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Bibliographic Details
Main Authors: Wenling Gao, Ronghan He, Jianhua Ren, Wenhui Zhang, Kun Wang, Lei Zhu, Tangzhao Liang
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:FEBS Open Bio
Subjects:
angiogenesis
bone marrow mesenchymal stem cells
exosome
HMGB1
hypoxia
Online Access:https://doi.org/10.1002/2211-5463.13142

Internet

https://doi.org/10.1002/2211-5463.13142

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