Survival motor neuron protein and neurite degeneration are regulated by Gemin3 in spinal muscular atrophy motoneurons

Survival motor neuron protein and neurite degeneration are regulated by Gemin3 in spinal muscular atrophy motoneurons

Spinal Muscular Atrophy (SMA) is a genetic neuromuscular disorder caused by reduction of the ubiquitously expressed protein Survival Motor Neuron (SMN). Low levels of SMN impact on spinal cord motoneurons (MNs) causing their degeneration and progressive muscle weakness and atrophy. To study the mole...

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Bibliographic Details
Main Authors: Maria P. Miralles, Alba Sansa, Maria Beltran, Rosa M. Soler, Ana Garcera
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Gemin3
spinal muscular atrophy
survival motor neuron
motoneuron
NF-κB pathway
RelA
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.1054270/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.1054270/full

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