Survival motor neuron protein and neurite degeneration are regulated by Gemin3 in spinal muscular atrophy motoneurons

Spinal Muscular Atrophy (SMA) is a genetic neuromuscular disorder caused by reduction of the ubiquitously expressed protein Survival Motor Neuron (SMN). Low levels of SMN impact on spinal cord motoneurons (MNs) causing their degeneration and progressive muscle weakness and atrophy. To study the mole...

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Detalhes bibliográficos
Main Authors: Maria P. Miralles, Alba Sansa, Maria Beltran, Rosa M. Soler, Ana Garcera
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2022-12-01
Colecção:Frontiers in Cellular Neuroscience
Assuntos:
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fncel.2022.1054270/full